KMID : 0043319850080040221
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Archives of Pharmacal Research 1985 Volume.8 No. 4 p.221 ~ p.227
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Studies on Triterpenoid Corticomimetics (IV) E-Ring Opending of Pormolic Acid by Retrograde Aldol Condensation
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Han YN
Han BH/Park ET/Kim TH
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Abstract
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Acetyl-11-ketopomolic acid methyl ester (VI), mp 276-278o, was synthesized from pomolic acid (III). The mild alkaline treatment of VI induced the opening of ring E on carbon skeleton to yield VII, and then VII was deacetylated to give VIII, mp 82-84o. Compound VIII was established as 11, 19-diketo-18,19-secoursolic acid methyl ester. The E-ring opening was believed to be due to retrograde aldol condensation.
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