KMID : 0043319990220020202
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Archives of Pharmacal Research 1999 Volume.22 No. 2 p.202 ~ p.207
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Synthesis and Biological Studies of Catechol Ether Type Derivatives as Potential Phosphodiesterase (PDE) IV Inhibitors
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Rhee Chung K.
Kim Jong-Hoon Suh Byung-Chul Xiang Myung-Xik Youn Yong-Sik Bang Won-Young Kim Eui-Kyung Shin Jae-Kyu Lee Youn-Ha
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Abstract
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New series of catechol ether type derivatives 5, 6 have been synthesized and applied to biological tests. Even though it is ap preliminary data, some of our target molecules show the promising result against PDE IV inhibition. SAR and biological studies with studies with synthetic compounds will be discussed in detail.
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KEYWORD
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Phosphodiesterase (PDE), Anti-asthma therapy, Structure-activity relationship (SAR), Catechol ether type PDE IV inhibitors
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