KMID : 0043320070300010022
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Archives of Pharmacal Research 2007 Volume.30 No. 1 p.22 ~ p.27
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A Concise Synthesis of a Promising Protein Kinase C Inhibitor: D-erythro-Sphingosine
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Pham Van-Thoai
Joo Jae-Eun Tian Yong-Shou Oh Chang-Young Ham Won-Hun
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Abstract
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In this study, we explored a convenient and concise route for synthesis of D-erythro-sphingosine 1 from commercially available and cheap L-serine. The key steps are simple preparation of amino ketone 5 from Weinreb amide 3 and high diastereoselective reduction of amino ketone 5 to give the natural erythro-(anti-) isomer.
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KEYWORD
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Sphingolipid, Sphingosine, Ceramide, Amino alcohol
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