KMID : 0043320080310080989
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Archives of Pharmacal Research 2008 Volume.31 No. 8 p.989 ~ p.994
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5-HT©üc Receptor Agonists with Potential Anorectic Activity
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Yoon Goo
Jeong Hee-Jin Kim Jeong-Ju Cheon Seung-Hoon
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Abstract
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Substituted 2,3,4,4a-tetrahydropyrazino[2,1-c][1,4]benzoxazin-5-(1H)-ones were synthesized and evaluated as receptor agonists for the possible treatment of obesity. A number of compounds exhibited agonist binding activity with compound 19 showing the most potent in vitro activity.
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KEYWORD
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5-HT©üc receptor agonist, Pyrazinobenoxazinone, Anorectic, Obesity
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