KMID : 0043320110340010087
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Archives of Pharmacal Research 2011 Volume.34 No. 1 p.87 ~ p.8690
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Crystal forms of naproxen
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Song Jung-Soon
Sohn Young-Taek
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Abstract
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The objective of this work was to investigate the existence of polymorphs and pseudopolymorphs of naproxen and the transformation of crystal forms. Four crystal forms of naproxen have been isolated by recrystallization and characterized by differential scanning calorimetry, powder X-ray diffractometry and thermogravimetric analysis. The differential scanning calorimetry and powder X-ray diffractometry patterns of the four crystal forms were different respectively. In the dissolution studies in pH 6.8 ¡¾ 0.05 buffer equilibrated at 37 ¡¾ 0.5¡ÆC, the solubility of four crystal forms was similar (within the error range). After storage of 1 month at 0% RH (silica gel, 20¡ÆC), 52% RH (saturated solution of Na2Cr2O7.2H2O/20¡ÆC) and 95% RH (saturated solution of Na2HPO4/20¡ÆC), Form 2 and Form 4 were transformed to Form 1, but Form 3 and Form 1 were not transformed and they were shown to have a good physical stability at room temperature for 1 month.
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KEYWORD
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Naproxen, Crystal form, Polymorphism, Pseudopolymorphism, Transformation, Dissolution, DSC, PXRD, TG
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