KMID : 0043320120350071159
|
|
Archives of Pharmacal Research 2012 Volume.35 No. 7 p.1159 ~ p.1168
|
|
The synthesis and characterization of fatty acid salts of chitosan as novel matrices for prolonged intragastric drug delivery
|
|
Bani Jaber Ahmad
Hamdan Imad Alkawareek Mahmoud
|
|
Abstract
|
|
|
The aim of this study was to prepare fatty acid salts of chitosan (CS) and to evaluate the salts as matrices for sustained drug release and prolonged gastric retention. CS-laurate and CS-palmitate were formed by mixing saturated CS solution and aqueous solutions of sodium laurate and sodium palmitate, respectively, and collected by centrifugation. They were characterized using Fourier-transform infrared spectroscopy and differential scanning calorimetry. Different matrices as effervescent tablets were prepared using each of these CS-salts, CS and the corresponding physical mixtures of CS and the fatty acids. Sodium bicarbonate as an effervescent agent and ranitidine HCl as a model drug were incorporated into these matrices. In vitro buoyancy and drug dissolution were studied for the matrices in 0.1 M HCl. Tablets with fatty acid salts of CS showed both rapid and prolonged buoyancy (> 8 h). Comparatively, CS tablets exhibited a short floatation period (< 2 h) and tablets were completely disintegrated within 1 h of soaking. In addition, slow and prolonged drug release was achieved from tablets of fatty acid salts of CS with average drug release of 80.1 and 71.8% for CS-laurate and CS-palmitate, respectively. Rapid drug release (> 80% at 1 h) was exhibited by tablets with CS or the physical mixtures.
|
|
KEYWORD
|
|
Chitosan, Chitosan-laurate, Chitosan-palmitate, Floating tablet, Sustained release
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|