KMID : 0043320120350122093
|
|
Archives of Pharmacal Research 2012 Volume.35 No. 12 p.2093 ~ p.2104
|
|
Synthesis and in vitro antitumor activities of xanthone derivatives containing 1,4-disubstituted-1,2,3-triazole moiety
|
|
Zou Yan
Zhao Qingjie Hu Honggang Hu Lina Yu Shichong Xu Mingjuan Wu Qiuye
|
|
Abstract
|
|
|
To explore the more active antitumor compounds, two series of new xanthones, containing 1,4-disubstituted-1,2,3-triazole moiety were designed and synthesized. Eaton¡¯s Reagent and ¡°click reaction¡± were used in the synthesis. Most of the title compounds showed good inhibitory activity against the hepatoma carcinoma cell line (Bel-7402) and human cervical carcinoma cell line (HeLa) in vitro. Compounds 10a, 10e, 10f, 11r and 11t had potent activity with IC50 values, ranging from 2.2 ¡¾ 0.17 to 7.1 ¡¾ 0.27 ¡ðM, which was equivalent to Doxorubicin.
|
|
KEYWORD
|
|
Xanthone, 1, 2, 3-Triazoles, Click chemistry, Antitumor activity
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|