KMID : 0043320120350122143
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Archives of Pharmacal Research 2012 Volume.35 No. 12 p.2143 ~ p.2146
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Two new natural products from the fruits of Alpinia oxyphylla with inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophage cells
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Qing Zhang Jun
Yong Wang Hui Li Yong Yong Lai Wei Long Li Hai Ao Duan Jin Xia Pei Li
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Abstract
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Chemical investigation of the fruits of Alpinia oxyphylla led to an isolation of the two new natural products, 9-hydroxy epinootkatol (1) and (S)-2-pentanol-2-O-¥â-D-glucopyranoside (2), in addition to the nine known compounds, pinocembrin (3), tectochrysin (4), izalpinin (5), nookatone (6), yakuchinone A (7), protocatechuic acid (8), ¥â-sitosterol (9), daucosterol (10) and ¥â-sitosterol palmitate (11). Their structures were elucidated on the basis of physicochemical constants and NMR spectral data analysis. The effects of the isolated components on nitric oxide production in LPS-induced RAW 264.7 macrophages were examined. The two new natural compounds showed inhibitory activities with IC50 values of 21.8 and 32.8 ¥ìg/mL, respectively.
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KEYWORD
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Zingerberaceae, Alpinia oxyphylla, Sesquiterpenoids, Structure elucidation, Antiinflammatory effects
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