KMID : 0043320130360080952
|
|
Archives of Pharmacal Research 2013 Volume.36 No. 8 p.952 ~ p.956
|
|
Prenylated indole diketopiperazine alkaloids from a mangrove rhizosphere soil derived fungus Aspergillus effuses H1-1
|
|
Gao Huquan
Zhu Tianjiao Li Dehai Gu Qianqun Liu Weizhong
|
|
Abstract
|
|
|
One new prenylated indole diketopiperazine alkaloid, named dihydroneochinulin B (1), one known spiro-polyketide-diketopiperazine hybrid cryptoechinuline D (2) and three related known metabolites didehydroechinulin B (3), neoechinulin B (4) and auroglaucin (5) were isolated from the mangrove rhizosphere soil derived fungus, Aspergillus effuses H1-1. The structures were assigned by detailed spectroscopic analysis. The enantiomers of cryptoechinuline D (2) were separated to be (+)-cryptoechinuline D (2a) and (?)-cryptoechinuline D (2b) by chiral HPLC, and their absolute configurations were determined by ECD analysis. The cytotoxic effects of the compounds were preliminarily evaluated on P388, HL-60, BEL-7402 and A-549 cell lines by SRB or MTT methods, and compounds 2, 2a and 3 showed significant activities.
|
|
KEYWORD
|
|
Aspergillus effuses, Mangrove, Metabolite, Alkaloids, Cytotoxic
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|