KMID : 0191119920070030189
|
|
Journal of Korean Medical Science 1992 Volume.7 No. 3 p.189 ~ p.192
|
|
Transcription of class II MHC gene by interferon-gamma in FRTL-5 cells
|
|
Lee MS
Lee JO/Kang TW/Lee JH
|
|
Abstract
|
|
|
The intracellular mechanism by which interferon-gamma induces the expression of class II
major histocompatibility complex (MHC) antigen in nonlymphoid cells is not clear. The effect of recombinant rat interferon-gamma (IFN-gamma), and cycloheximide on the expression of class II MHC gene was studied using the techniques of immunocytochemical staining and northern blot analysis. IFN-gamma induced de novo transcription of class II MHC gene and class II MHC antigen expression on the cell surface. Cycloheximide did not inhibit IFN-gamma-induced class II MHC antigen expression in a dose-dependent manner indicating translational blockade. These results
suggest that IFN-gamma induces class II MHC antigen expression via de novo transcription of class II MHC gene leading to synthesis of new class II MHC molecule.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|