KMID : 0191120080230020296
|
|
Journal of Korean Medical Science 2008 Volume.23 No. 2 p.296 ~ p.301
|
|
Impact of Caveolin-1 Expression on the Prognosis of Transitional Cell Carcinoma of the Upper Urinary Tract
|
|
Cho Dae-Sung
Hong Sung-Joon Yim Hyun-Ee Kim Sun-Il Kim Se-Joong Ahn Hyun-Soo Cho Nam-Hoon Cho Kang-Su
|
|
Abstract
|
|
|
This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCCUUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin- 1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.
|
|
KEYWORD
|
|
Caveolin 1, Prognosis, Carcinoma, Transitional Cell, Upper Urinary Tract
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|