KMID : 0191120090240040744
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Journal of Korean Medical Science 2009 Volume.24 No. 4 p.744 ~ p.746
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Successful Salvage Unrelated Umbilical Cord Blood Transplantation with Two Units After Engraftment Failure with Single Unit in Severe Aplastic Anemia
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Lee Ji-Won
Kang Hyoung-Jin Kim Eun-Kyung Shin Hee-Young Ahn Hyo-Seop
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Abstract
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Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a single unit. Two-unit UCBT is proposed to have better engraftment potential and to offer a better chance of survival, according to some reports. Increased cell dose and graft-versus-graft reaction could contribute to these advantages. With this promising result, two-unit UCBT could be an alternative treatment option for patients with SAA without an HLA-matched donor.
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KEYWORD
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Anemia, Aplastic, Cord Blood Stem Cell Transplantation, Two-unit
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