KMID : 0191120090240040747
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Journal of Korean Medical Science 2009 Volume.24 No. 4 p.747 ~ p.750
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A Case of Wernicke¡¯s Encephalopathy Following Fluorouracil-based Chemotherapy
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Cho In-Jeong
Chang Hye-Jung Lee Kyung-Eun Won Hye-Sung Choi Moon-Young Nam Eun-Mi Mun Yeung-Chul Lee Soon-Nam Seong Chu-Myong
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Abstract
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The pyrimidine antimetabolite 5-fluorouracil (5-FU) is a chemotherapeutic agent used widely for various tumors. Common side effects of 5-FU are related to its effects on the bone marrow and gastrointestinal epithelium. Neurotoxicity caused by 5-FU is uncommon, although acute and delayed forms have been reported. Wernicke¡¯s encephalopathy is an acute, neuropsychiatric syndrome resulting from thiamine deficiency, and has significant morbidity and mortality. Central nervous system neurotoxicity such as Wernicke¡¯s encephalopathy following chemotherapy with 5-FU has been reported rarely, although it has been suggested that 5-FU can produce adverse neurological effects by causing thiamine deficiency. We report a patient with Wernicke¡¯s encephalopathy, reversible with thiamine therapy, associated with 5-FU-based chemotherapy.
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KEYWORD
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Fluorouracil, Wernicke¡¯s Encephalopathy, Thiamine
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