KMID : 0191120160310020286
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Journal of Korean Medical Science 2016 Volume.31 No. 2 p.286 ~ p.295
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Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment
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Seo Eun-Hyun
Kim Sang-Hoon Park Sang-Hag Kang Seong-Ho Choo Il-Han Alzheimers Disease Neuroimaging Initiative
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Abstract
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This study aimed to investigate the independent and interactive influences of apolipoprotein E (APOE) ¥å4 and beta-amyloid (A¥â) on multiple cognitive domains in a large group of cognitively normal (CN) individuals and patients with mild cognitive impairment (MCI) and Alzheimer¡¯s disease (AD). Participants were included if clinical and cognitive assessments, amyloid imaging, and APOE genotype were all available from the Alzheimer¡¯s Disease Neuroimaging Initiative database (CN = 324, MCI = 502, AD = 182). Individuals with one or two copies of ¥å4 were designated as APOE ¥å4 carriers (¥å4+); individuals with no ¥å4 were designated as APOE ¥å4 non-carriers (¥å4?). Based on mean florbetapir standard uptake value ratios, participants were classified as A¥â burden-positive (A¥â+) or A¥â burden-negative (A¥â?). In MCI, APOE ¥å4 effects were predominantly observed on frontal executive function, with ¥å4+ participants exhibiting poorer performances; A¥â positivity had no influence on this effect. A¥â effects were observed on global cognition, memory, and visuospatial ability, with A¥â+ participants exhibiting poorer performances. Measures of frontal executive function were not influenced by A¥â. Interactive effects of APOE ¥å4+ and A¥â were observed on global cognition and verbal recognition memory. A¥â, not APOE ¥å4+, influenced clinical severity and functional status. The influences of APOE ¥å4+ and A¥â on cognitive function were minimal in CN and AD. In conclusion, we provide further evidence of both independent and interactive influences of APOE ¥å4+ and A¥â on cognitive function in MCI, with APOE ¥å4+ and A¥â showing dissociable effects on executive and non-executive functions, respectively.
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KEYWORD
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Alzheimer Disease, Mild Cognitive Impairment, APOE ¥å4+, Beta-amyloid Burden, Neuropsychology
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