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KMID : 0191120180330530342
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Journal of Korean Medical Science
2018 Volume.33 No. 53 p.342 ~ p.342
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Clinical Validation of a Protein Biomarker Panel for Non-Small Cell Lung Cancer
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Jung Young-Ju
Oh In-Jae
Kim Youn-Dong
Jung Jong-Ha
Seok Min-Kyoung
Lee Woo-Chang
Park Cheol-Kyu
Lim Jung-Hwan
Kim Young-Chul
Kim Woo-Sung
Choi Chang-Min
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Abstract
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We validated the diagnostic performance of a previously developed blood-based 7-protein biomarker panel, AptoDetect™-Lung (Aptamer Sciences Inc., Pohang, Korea) using modified aptamer-based proteomic technology for lung cancer detection. Non-small cell lung cancer (NSCLC), 200 patients and benign nodule controls, 200 participants were enrolled. In a high-risk population corresponding to ≥ 55 years of age and ≥ 30 pack-years, the diagnostic performance was improved, showing 73.3% sensitivity and 90.5% specificity with an area under the curve of 0.88. AptoDetect™-Lung (Aptamer Sciences Inc.) offers the best validated performance to discriminate NSCLC from benign nodule controls in a high-risk population and could play a complementary role in lung cancer screening.
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KEYWORD
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Aptamer, Lung Cancer Screening, Lung Nodule, Computed Tomography
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