KMID : 0191120190340020017
|
|
Journal of Korean Medical Science 2019 Volume.34 No. 2 p.17 ~ p.17
|
|
Evaluation of a Carbapenem-Saving Strategy Using Empirical Combination Regimen of Piperacillin-Tazobactam and Amikacin in Hemato-Oncology Patients
|
|
Ko Jae-Hoon
Kim Si-Ho Kang Cheol-In Cho Sun-Young Lee Nam-Yong Chung Doo-Ryeon Peck Kyong-Ran Song Jae-Hoon
|
|
Abstract
|
|
|
We implemented a carbapenem-saving strategy in hemato-oncology patients from 2013, using an empirical combination of piperacillin-tazobactam and amikacin for high-risk hemato-oncology patients with febrile neutropenia, who remain hemodynamically unstable > 72 hours despite initial cefepime treatment. All-cause mortality was not different between the two periods (6.54 and 6.57 deaths per 1,000 person-day, P = 0.926). Group 2 carbapenem use significantly decreased after strategy implementation (78.43 vs. 67.43 monthly days of therapy, P = 0.018), while carbapenem-resistant gram-negative bacilli did not show meaningful changes during the study period. Our carbapenem-saving strategy could effectively suppress carbapenem use without an increase of overall mortality.
|
|
KEYWORD
|
|
Carbapenem-Saving, Piperacillin-Tazobactam, Amikacin, Gram-Negative Bacilli, Resistance
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|