KMID : 0191120220370350267
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Journal of Korean Medical Science 2022 Volume.37 No. 35 p.267 ~ p.267
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Relative Effectiveness of COVID-19 Vaccination in Healthcare Workers: 3-Dose Versus 2-Dose Vaccination
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Kim Sung-Ran
Kang hyeon-Jeong Jeong Hye-Rin Jang Su-Yeon Lee Jae-Eun Kim Da-Eun Lee Hae-Ry Cho Min-Hee Noh Ji-Yun Cheong Hee-Jin Kim Woo-Joo Song Joon-Young
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Abstract
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The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to have high infectivity and is more likely to evade vaccine immunity. However, booster vaccination is expected to strengthen cross-reactive immunity, thereby increasing the vaccine effectiveness (VE). This study aimed to evaluate the relative VE of the 3-dose (booster) vaccination compared with the 2-dose primary series vaccination in healthcare workers during omicron variant-dominant periods. During the omicron-dominant period from February 1, 2022 to February 28, 2022, a 1:1 matched case-control study was conducted. Healthcare workers with positive SARS-CoV-2 test results were classified as positive cases, whereas those with negative results served as controls. Compared with the 2-dose primary series vaccination, booster vaccination with mRNA vaccine showed moderate VE (53.1%). However, in multivariate analysis including the time elapsed after vaccination, the significant VE disappeared, reflecting the impact of recent vaccination rather than the third dose itself.
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KEYWORD
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SARS-CoV-2, COVID-19, Healthcare Worker, Vaccine Effectiveness
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