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KMID : 0213520070210040189
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Korean Journal of Ophthalmology
2007 Volume.21 No. 4 p.189 ~ p.194
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Short Term Effects of Topical Cyclosporine and Viscoelastic on the Ocular Surfaces in Patients with Dry Eye
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Moon Jun-Woong
Lee Hyun-Joo
Shin Ki-Cheul
Wee Won-Ryang
Lee Jin-Hak
Kim Mee-Kum
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Abstract
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Purpose: To compare the short term effects of topical 0.05% cyclosporine (CsA) and a mixture of 0.08% chondroitin sulfate and 0.06% sodium hyaluronate (CS-HA) on dry eye ocular surfaces.
Methods: 36 patients with moderate to severe dry eye (5 mm/5 min or less with Schirmer`s test or tear break up time (BUT) less than 6 seconds), were treated with topical application of CS-HA on one eye and CsA on the other 4 times a day for 6-8 weeks. BUT, Schirmer`s test without anesthesia, and conjunctival impression cytology (CIC; goblet cell density, nucleus to cytoplasmic ratio, and epithelial cell morphology) were evaluated and compared between eyes before and after treatment (repeated measurement of ANOVA).
Results: After treatment, BUT and tear wettings were significantly prolonged in each group. Topical CsA treated eyes had greater increase in BUT (p=0.026); there was no significant difference in tear wetting (p=0.132). While the 3 parameters of CIC improved in both groups, goblet cell density was significantly higher in eyes treated with CsA (p=0.033).
Conclusions: While both CS-HA and 0.05% CsA eyedrops improve ocular surfaces, topical CsA may have a better effect on enhancing tear film stability and goblet cell density
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KEYWORD
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Dry eye, Topical cyclosporine, Topical viscoelastic
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