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KMID : 0213520090230010046
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Korean Journal of Ophthalmology
2009 Volume.23 No. 1 p.46 ~ p.48
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Topical and Oral Voriconazole in the Treatment of Fungal Keratitis
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Lee Sang-Joon
Lee Jung-Joo
Kim Shin-Dong
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Abstract
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We describe two patients with fungal keratitis refractory to standard antifungal therapy whose conditions were managed with voriconazole. The first case is a patient with endophthalmitis and corneal ulcer due to Candida parapsilosis after receiving a corneal transplant. The patient was treated with amphotericin but showed no signs of improvement. Topical voriconazole, oral voriconazole, and intravitreal voriconazole yielded signs of improvement. The second case is a 63-year-old male who underwent a month of empiric treatment with 0.2% topical amphotericin for fungal keratitis but showed no signs of improvement. Treatment was then provided with 1% voriconazole. Both cases showed effective treatment with voriconazole. Voriconazole may be considered as a new method to treat fungal keratitis refractory to standard antifungal therapy.
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KEYWORD
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Fungus, Keratitis, Voriconazole
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