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KMID : 0213520090230030193
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Korean Journal of Ophthalmology
2009 Volume.23 No. 3 p.193 ~ p.197
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C-reactive Protein and Lipid Profiles in Korean Patients With Normal Tension Glaucoma
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Choi Jae-Wan
Joe Soo-Geun
Seong Min-Cheol
Choi Jin-Young
Sung Kyung-Rim
Kook Michael S.
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Abstract
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Purpose: To compare high-sensitivity C-reactive protein (hsCRP) levels and lipid profiles between Korean normal tension glaucoma (NTG) patients and healthy controls.
Methods: This cross-sectional study included 38 Korean patients with NTG and 38 age- and sex-matched healthy control subjects. We excluded the patients with cardiovascular risk factors and other systemic diseases that might affect CRP levels and lipid profiles. Each patient underwent a Humphrey visual field examination and blood sampling for hsCRP and lipid profile analyses. Subsequently, the NTG patients were classified into two groups based on their untreated intraocular pressure (IOP) level: low NTG (LNTG) with IOP≤13 mmHg (13 subjects) and high NTG (HNTG) with relatively high IOP (>13 and ≤21 mmHg, 25 subjects). The hsCRP levels and lipid profiles were compared between NTG patients and healthy controls, and between LNTG, HNTG, and healthy controls.
Results: There were no significant differences in hsCRP and lipid profiles between either the NTG patients and healthy controls, or between the LNTG, HNTG, and controls (p>0.05) after exclusion of Korean patients with cardiovascular risk factors. There was no significant association between hsCRP and visual field indices (p>0.05).
Conclusions: High-sensitivity C-reactive protein-related vascular inflammatory conditions may not be directly associated with the development of NTG, regardless of the untreated IOP level.
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KEYWORD
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Atherosclerosis, C-reactive protein, Lipid profiles, Normal tension glaucoma
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