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KMID : 0213520110250020105
Korean Journal of Ophthalmology
2011 Volume.25 No. 2 p.105 ~ p.109
Inter-Device Agreement of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Cirrus HD OCT
Hong Sa-Min

Kim Yeong-Jun
Shim Jong-Woo
Kim Chan-Yun
Seong Gong-Je
Abstract
Purpose: To assess the inter-device agreement of peripapillary retinal nerve fiber layer (RNFL) thickness measurements by 2 spectral domain Cirrus HD optical coherence tomography (OCT) devices in healthy Korean subjects.

Methods: Eleven eyes of 11 healthy volunteers were enrolled in the present study. Each eye was scanned with the Optic Disc Cube 200 ¡¿ 200 scan of 2 Cirrus HD OCT devices for peripapillary RNFL thickness calculation. The inter-device agreements of the 2 Cirrus HD OCTs for average, quadrant, and clock-hour RNFL thickness values were determined with Wilcoxon signed rank test, Friedman test, Cronbach¡¯s alpha (¥á), intraclass correlation coefficient (ICC), coefficient of variation (COV), and Bland-Altman plot.

Results: The mean age of the participants was 25.82 ¡¾ 3.28 years and all had a 0.00 logarithm of the minimum angle of resolution of best-corrected visual acuity. The signal strengths of scans from the 2 Cirrus HD OCT were not significantly different (p = 0.317). The inter-device agreement of average RNFL thickness was excellent (¥á, 0.940; ICC, 0.945; COV, 2.45 ¡¾ 1.52%). However, the agreement of nasal quadrant RNFL thickness was not very good (¥á, 0.715; ICC, 0.716; COV, 5.72 ¡¾ 4.64%). Additionally, on the Bland-Atman plot, the extent of agreement of the 2 Cirrus HD OCTs for RNFL thickness was variable according to scanned sectors.

Conclusions: The inter-device agreement of 2 spectral domain Cirrus HD OCT devices for peripapillary RNFL thickness measurements was generally excellent but variable according to the scanned area. Thus, physicians should consider this fact before judging a change of RNFL thicknesses if they were measured by different OCT devices.
KEYWORD
Inter-device agreement, Optical coherence tomography, Retinal nerve fiber layer thickness
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