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KMID : 0213520110250050355
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Korean Journal of Ophthalmology
2011 Volume.25 No. 5 p.355 ~ p.357
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Vortex Keratopathy in a Patient Receiving Vandetanib for Non-Small Cell Lung Cancer
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Ahn Jee-Yun
Wee Won-Ryang
Lee Jin-Hak
Hyon Joon-Young
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Abstract
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We report a case of vortex keratopathy in a patient treated with vandetanib for non-small cell lung cancer (NSCLC). A 44-year-old female who underwent two cycles of chemotherapy for NSCLC complained of visual blurring in both eyes after the initiation of vandetanib, an anti-epidermal growth factor receptor (EGFR) and anti-vascular endothelial growth factor receptor 2 protein tyrosine kinase inhibitor. On ophthalmic examination, visual acuities were 20 / 20 OU and, with the exception of diffuse vortex keratopathy in both eyes, other findings were unremarkable. Vandetanib is believed to have caused vortex keratopathy in this patient. Anti-EGFR properties affecting normal corneal epithelial cell migration and wound healing or drug associated metabolite deposition, which is the case in numerous drug-associated vortex keratopathies, may be possible underlying mechanisms in the formation of this corneal complication.
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KEYWORD
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Epidermal growth factor, Vandetanib, Vortex keratopathy
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