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KMID : 0213520140280060460
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Korean Journal of Ophthalmology
2014 Volume.28 No. 6 p.460 ~ p.465
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Elevated Plasma Pentraxin 3 and Its Association with Retinal Vein Occlusion
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Park Kyung-Soo
Kim Ji-Wan
An Jae-Hwan
Woo Je-Moon
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Abstract
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Purpose: To evaluate plasma pentraxin 3 (PTX3) in patients with retinal vein occlusion (RVO), and investigate the possibility of its role as a predictive biomarker.
Methods: Nested case-control study. The study included 57 patients with RVO and 45 age- and gender-matched subjects without RVO as controls. Plasma PTX3 and C-reactive protein concentration were measured in both groups a posteriori from frozen samples by using an enzyme-linked immunosorbent assay kit.
Results: The measured PTX3 value for the RVO group was 1,508 ± 1,183 pg/mL (mean ± standard deviation) and 833 ± 422 pg/mL for the controls (p < 0.001). There was no significant difference in PTX3 levels between patients with central retinal vein occlusion and branched retinal vein occlusion (1,468 ± 1,300 vs. 1,533 ± 1,121 pg/mL; p = 0.818).
Conclusions: Our data seems to support the role of chronic inflammation and ischemia in the development of RVO. It is possible that PTX3 can be used as a diagnostic biomarker of RVO.
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KEYWORD
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Biological markers, Inflammation, Ischemia, Pentraxin3, Retinal vein occlusion
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