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KMID : 0213520150290020131
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Korean Journal of Ophthalmology
2015 Volume.29 No. 2 p.131 ~ p.137
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Efficacy of the Mineral Oil and Hyaluronic Acid Mixture Eye Drops in Murine Dry Eye
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Choi Jung-Han
Kim Jung-Han
Li Zhengri
Oh Han-Jin
Ahn Kyu-Youn
Yoon Kyung-Chul
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Abstract
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Purpose: To investigate the therapeutic effects of mineral oil (MO) and hyaluronic acid (HA) mixture eye drops
on the tear film and ocular surface in a mouse model of experimental dry eye (EDE).
Methods: Eye drops consisting of 0.1% HA alone or mixed with 0.1%, 0.5%, or 5.0% MO were applied to desiccating
stress-induced murine dry eyes. Tear volume, corneal irregularity score, tear film break-up time (TBUT), and corneal fluorescein staining scores were measured at 5 and 10 days after treatment. Ten days after treatment, goblet cells in the conjunctiva were counted after Periodic acid-Schiff staining.
Results: There was no significant difference in the tear volume between desiccating stress-induced groups. The corneal irregularity score was lower in the 0.5% MO group compared with the EDE and HA groups. The 0.5% and 5.0% MO groups showed a significant improvement in TBUT compared with the EDE group. Mice treated with 0.1% and 0.5% MO mixture eye drops showed a significant improvement in fluorescein staining scores compared with the EDE group and the HA group. The conjunctival goblet cell count was higher in the 0.5% MO group compared with the EDE group and HA group.
Conclusions: The MO and HA mixture eye drops had a beneficial effect on the tear films and ocular surface of murine dry eye. The application of 0.5% MO and 0.1% HA mixture eye drops could improve corneal irregularity, the corneal fluorescein staining score, and conjunctival goblet cell count compared with 0.1% HA eye drops in the treatment of EDE.
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KEYWORD
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Dry eye, Hyaluronic acid, Mineral oil, Ocular surface
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