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KMID : 0213520150290050325
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Korean Journal of Ophthalmology
2015 Volume.29 No. 5 p.325 ~ p.330
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Sterile Inflammation after Intravitreal Injection of Aflibercept in a Korean Population
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Kim Ju-Young
You Yong-Sung
Kwon Oh-Woong
Kim Soon-Hyun
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Abstract
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Purpose: To report the frequency and clinical features of sterile inflammation after intravitreal aflibercept injection in a Korean population.
Methods: A single-center, retrospective study was performed in patients who received intravitreal aflibercept from July 2013 through January 2015.
Results: A total of four cases of post-injection sterile inflammation were identified from 723 aflibercept injections in 233 patients. Patients presented 1 to 13 days after intravitreal aflibercept injection (mean, 5 days). The mean baseline visual acuity was 20 / 60, which decreased to 20 / 112 at diagnosis but ultimately recovered to 20 / 60. Three cases had inflammatory cells in the anterior chamber (mean, 2.25+; range, 0 to 4+), and all cases had vitritis (mean, 3+; range, 2+ to 4+). No patients had pain. Only one patient underwent anterior chamber sampling (culture negative) and injection of antibiotics. Three of four patients were treated with a topical steroid, and all experienced improvement in their symptoms and signs of inflammation.
Conclusions: The overall incidence of sterile inflammation after intravitreal aflibercept injection in a Korean population was 4 of 723 injections (0.55%), or 4 of 233 patients (1.79%). Sterile inflammation after intravitreal aflibercept injection typically presents without pain, and the visual outcomes are generally favorable.
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KEYWORD
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Aflibercept, Intravitreal injections, Sterile inflammation
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