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KMID : 0213520230370030236
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Korean Journal of Ophthalmology
2023 Volume.37 No. 3 p.236 ~ p.244
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Comparison of Corneal Epithelial Wound Healing between Topical RCI001, Solcoseryl, and Polydeoxyribonucleotide in the Murine Ocular Alkali Burn Model
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Song Myung-Sun
Ku Young-Ah
Kim Seung-Hoon
Chung Myung-Hee
Kim Yong-Ho
Kim Dong-Hyun
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Abstract
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Purpose: To compare the corneal epithelial wound healing effects of RCI001, Solcoseryl, and polydeoxyribonucleotide (PDRN)in a rat alkali burn model.
Methods: In 40 male Sprague-Dawley rats, we induced alkali burn using filter paper soaked in 0.2N sodium hydroxide. Therats were then treated with topical 0.5% RCI001, 1.0% RCI001, Solcoseryl, or PDRN twice a day for 2 weeks. Corneal epithelialintegrity and epithelial healing rate were measured at day 0, 3, 5, 7, 10, and 14. Histologic and immunohistochemistry findingswere also assessed.
Results: Both the 0.5% and 1.0% RCI001 groups showed significantly more epithelial healing compared to the control groupat day 5, 7, 10, and 14 (each p < 0.05). No statistical difference was found between the 0.5% and 1.0% RCI001 groups. Neitherthe Solcoseryl nor the PDRN groups showed a significant difference from the control. RCI001 treatment resulted in significantlyreduced stromal edema, and a trend towards less inflammatory cell infiltration.
Conclusions: Topical application of RCI001 showed enhanced corneal epithelial wound healing in the murine corneal alkaliburn model, presumably by suppressing inflammation. Meanwhile, Solcoseryl and PDRN did not show sufficient therapeuticeffects compared to RCI001.
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KEYWORD
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Corneal epithelium, Polydeoxyribonucleotides, RCI001, Solcoseryl, Wound healing
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