|
KMID : 0311119670080010071
|
|
Yonsei Medical Journal
1967 Volume.8 No. 1 p.71 ~ p.76
|
|
|
Juvenile Pernicious Anemia in Sisters
|
|
Yun Duk-Jin
Lee Hyun
Chun Goeng-Pil
Lee Ki-Young
|
|
|
Abstract
|
|
|
Two cases of juvenile pernicious anemia in Korean sisters have been followed for 4 years since 7 years and 4 years of age respectively. The symptoms and signs were pale facies, general malaise, sore tongue, anorexia, frequent febrile episodes, macrocytic hyperchromic anemia, thrombocytopenia, multilobulated leucocytes with more than 6 lobules and megaloblastic proliferation in bone marrow aspiration. Dramatic hematological response to the parenteral administration of vitamin B12 with a significantly increased excretion rate of vitamin Bl2 by Schilling test as shown by an increase from 0 to 11.6% in elder sister and from 0 to 5.6% in younger sister with the addition of commercial intrinsic factor were demonstrated.
These findings are compatible with the characteristics of juvenile pernicious anemia resulting from defect of Cast1e’s intrinsic factor.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|