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KMID : 0311119690100010001
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Yonsei Medical Journal
1969 Volume.10 No. 1 p.1 ~ p.9
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Effect of Hypophysectomy, Adrenalectomy and Thyroidectomy on the Beta-Cells of the Islets of Langerhans of the Pancreas
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Lee, Hun Joo
Lee, Yoo Bock/Kim, Dong Sik
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Abstract
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Prolonged administration of anterior hypophyseal, adrenocortical, or thyroid hormones is known to cause degeneration, degranulation and necrosis of the beta-cells in the Langerhans islets of the pancreas. However, the effects of extirpation of these endocrine glands upon the Langerhans islets has not been re-ported, although it is known that removal of any of these glands bring about hypoglycemia, decreased tissue uptake of glucose, and increased tissue sensitivity to insulin. The present investigation is studies of the morphologic alterations of the beta-cells in the Langerhans islets following hypophysectomy, adrenalectomy, or thyroidectomy in rats.
Hypophysectomy, adrenalectomy, and thyroidectomy, all. induce similar morphologic alterations in the beta-cells of the islets. These consist of in-creased beta-cell population, the accumulation of beta-granules, and atrophy of the individual beta-cell. Therefore, these changes are considered to be not specific following the withdrawal of specific hormones but a common effect of the hypoglycemia due to removal of the hypophysis, adrenals, or thyroid glands. A similar common degeneration of the beta-cells due to hyperglycemia occurs when hormones of these endocrine glands are given excessively.
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