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KMID : 0311119700110020085
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Yonsei Medical Journal
1970 Volume.11 No. 2 p.85 ~ p.94
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Liver Cells of Cordotomized Rats after Sing1e Doses of Carbon Tetrachloride
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Shin Tai-Sun
Choi Kum-Duck
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Abstract
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In attempting to ellucidate the mechanism of action of CCI₄toxicity on the liver, the histological and histochemical studies were carried out, at the cellular or ultrastructural level, rats were given a single oral dose of 1.25 ml/kg of CCI₄one hour after cervical spinal cordotomy.
Hepatic lesions induced by CC₄administration such as the fatty change of hepatic cells and the sinusoidal congestion were abolished by cordotomy. The decreased activities of adenosine triphosphatase and alkaline phosphatase in the hepatic cells and bile canaliculi of the poisoned animals were restored to a large extent by the operation. Cordotomy also prevented some liver cell changes as seen by the electron microscope in the CC₄-intoxicated rats. It is evident that the hepatotoxic effects of carbon tetrachloride can be inhibited or prevented by cervical cordotomy.
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