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KMID : 0311119740150020115
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Yonsei Medical Journal
1974 Volume.15 No. 2 p.115 ~ p.127
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Acute Serum Sickness Induced Immunologic Injury of the Choroid Plexus
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Choi, In Joon
Cho, Sang Ho/Kim, Dong Sik
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Abstract
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Immune complex deposits have been found in the choroid plexus in patients with systemic lupus erythematosus, and it can be assumed that an immune complex injury to the choroid plexus might be related to the neuropsychiatric disorder seen in patients with SLE. Acute serum sickness was experimentally induced in rabbits by intravenous injection of crystalized BSA. Prednisolone in conventionl dosage was administered to study the immunologic injury of the choroid plexus as well as the mechanisms involved in the prednisolone effect. Light, electron microscopic and immunofluorescent studies were made.
The host immunoglobulins (IgG,IgA, IgM) and beta 1 C globulin were demonstrated in the choroid plexus. Histopathological findings included mild to moderate interstitial and perivascular lymphocyte and plasma cell infiltrations and edema. Control animals showed no immune deposits and no histopathologic changes. Electron microscopic findngs comparing the immunofluorescent and histopathologic changes were minimal, and showed spartse, vague electron dense deposits particulatly in the interstirial spaces, Knob-like focal thickening of vascular basement membrane, swelling of endothelial cells,
and some accentuation of interstitial cells. The morphologic and functional similarities of the choroid plexus and glomerulat basement membrane, the findings in morphologic, electron microscopic and immunofluorescent examinations of the experimental rabbits, along with the observed effects of prednisolone, together with similar reports in the recent literature suggest that immunologic injury of the choroid plexus could be considered as a new disease entity. This immunologic injury might play a significant role in neuropsychiatric disorders in the longstanding immune complex deposit diseases.
The very interesting finding is the nature and function of the interstitial cell between the endothelial (vascular) and epithelial side basement membranes, and speculation as to whether or not the role of this interstitial cell in choroid plexus injury may be in its possible analogy with glomerular measngial cells.
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KEYWORD
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