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KMID : 0311119780190010007
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Yonsei Medical Journal
1978 Volume.19 No. 1 p.7 ~ p.15
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Detailed Analysis of Chromosome Aberrations in Human Leukocyte Induced by Anti-malignant Tumor Agent (FT-207)
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Hahn Sahsook
Kim Dong-Sik
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Abstract
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The anticancer agent´s, FT-207, N₁-(2´-tetrahydrofuryl)-5-fluorouracil, a derivative of 5FU (5-fluorouracil), induced chromosome damage to the human leukocyte was investigated. FT-207 inhibit mitosis and cause chromatid and chromosome breakage and chromatid exchange with 20 ㎍/㎖ for 48 to 72 hours of treatment. However, with 15 ㎍/㎖ for 72 hours only delayed spiralization was produced in some of the chromosomes in the same cells.
The random distribution of chromosome breakage were observed and the effect of FT-207 on the chromosomes of human leukocytes were time dependent rather than concentration dependent. The comparision of the effect of mitomycin C on human leukocytes and the action of FT-207 at specific times during the cell cycle were discussed.
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KEYWORD
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