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KMID : 0311119800210010024
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Yonsei Medical Journal
1980 Volume.21 No. 1 p.24 ~ p.35
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Problems Associated with I-125 Oxytocin Binding to Membrane Receptors
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Kim, In Kyo
Choi, Jung Ok/Kang, Doo Hee
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Abstract
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Radioiodinated oxytocin prepared by the lactoperoxidase method exhibited a substantial biologic activity in uterotonic assay of the rat uterus.
^(125)I-oxytocin was bound to the uterine membrane particulate fraction, but the unlabelled oxytocin did not inhibit the binding of ^(125)I oxytocin to the membrane fraction of rat uterus. Cold iodinated oxytocin, however, inhibited the ^(125)I-oxytocin binding to the membrane fraction of rat uterus in proportion to its concentration.
These results suggest that ^(125)I-oxytocin is not a suitable radioligand for oxytocin receptor binding study.
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