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KMID : 0311119800210020099
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Yonsei Medical Journal
1980 Volume.21 No. 2 p.99 ~ p.105
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Effects of Pancreatic Polypeptide on the Secretion of Enzymes and Electrolytes by in Vitro Preparations of Rat and Cat Pancreas
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Kim Kyung-Hwan
R. Maynard Case
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Abstract
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Pancreatic polypeptide (PP) is released from the pancreas in response to
tion. Amongst other effects, PP has been reported to inhibit pancreatic exoc ~ Apart from any potential physiological role, such inhibition could have important consequences for in vitro studies of pancreatic function employing acetylcholine as a stimulus. We have therefore tested the effect of bovine PP on two in vitro pancreatic preparations: the incubated, uncinate pancreas of young rats and the perfused cat pancreas. In the former, PP (10^(-10) - 10^(-8)M) had little or no effect on enzyme discharge or^(45)Ca efflux under basal conditions or during stimulation with caerulein, CCK-PZ or acetylcholine. In the perfused cat pancreas, similar concentrations of PP were also without effect on fluid secretion evoked by secretin infusion, or enzyme discharge evoked by CCK PZ injection or infusion. We conclude that bovine PP has no direct effects on the cellular mechanisms responsible for pancreatic electrolyte secretion or enzyme discharge in the species studied.
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