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KMID : 0311119980390040390
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Yonsei Medical Journal
1998 Volume.39 No. 4 p.390 ~ p.394
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A Case with Sarcomatoid Hepatocellular Carcinoma
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Jae Ho Han
Young Nyun Park/Woo Hee Jung/Hoon Sang Chi/Chanil Park
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Abstract
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Hepatocellular carcinoma (HCC) with sarcomatous features is a rare neoplasm which has been found in only 1.8% of surgically resected HCC and has a higher incidence of metastasis than usual HCC. We recently experienced a case of sarcomatoid HCC removed from a 49-year-old man. A surgically resected liver revealed a well-defined grayish-white solid firm mass showing extensive central necrosis and infiltrative growth margin. Microscopically, the entire tumor was composed of pleomorphic spindle cells with prominent nucleoli and frequent mitosis. It showed a sinusoidal infiltrative growth pattern at the tumor-nontumor boundary. The tumor cells reacted positively with AE3 (high molecular cytokeratin) and Vimentin and reacted negatively with AE1 (low molecular cytokeratin), cytokeratin19, carcinoembryonic antigen, alpha-fetoprotein, Factor VIII, CD31 and CD68. The spindle-shaped tumor cells were considered to originate from hepatocyte rather than from bile duct epithelium or mesenchymal elements.
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KEYWORD
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Hepatocellular carcinoma, sarcomatoid, liver,
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