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KMID : 0311119990400020112
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Yonsei Medical Journal
1999 Volume.40 No. 2 p.112 ~ p.117
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4-Aminopyridine (4-AP) Augments Ca2?-dependent Action Potential and Changes Oscillatory Firing Patterns in Rat Cerebellar Purkinje Cells
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Wha Sook Seo
Jung Hoon Shin/Chang Kook Suh
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Abstract
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Intracellular recordings in cerebellar slice preparation showed that applications of 4-AP altered the pattern of oscillatory firing activity in Purkinje cells (PCs), especially yielding pronounced changes in action potential shape. 4-AP increased the amplitude and duration of action potential significantly and decreased the spike frequency. After 4-AP application, the duration of bursting was prolonged and the duration of after-burst hyperpolarization was progressively shortened. In all PCs tested, the rhythmicity of oscillatory firing activity was abolished completely at the steady state. These results suggest that 4-AP-sensitive currents determine the shape and frequency of individual Ca2+-dependent action potentials as well as maintaining oscillatory firing activity in PCs.
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KEYWORD
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Purkinje cells, oscillatory firing activity, 4-aminopyridine (4-AP), 4-AP-sensitive current,
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