Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0311119990400020118
Yonsei Medical Journal
1999 Volume.40 No. 2 p.118 ~ p.123
The Loss of Expression of Transforming Growth Factor-¥â Receptors Correlates with the Histopathologic Tumor Grade in Bladder Transitional Cell Carcinoma Patients
Dong Hyeon Lee
Seung Choul Yang/Sung Joon Hong/Byung Ha Chung/Hyun Jik Chung/Hideo Tokunaga/Isaac Y. Kim/Yun S Song/Seth P Lerner/Ronald A Morton Jr
Abstract
Transforming growth factor-¥â (TGF-¥â), a pleiotropic growth factor, is a potent inhibitor of cellular proliferation in cells of epithelial origin. Recently, it has been suggested that a loss of sensitivity to TGF-¥â through a loss of expression of TGF-¥â receptors T ¥â R-I and T ¥â R-II--is associated with tumor initiation and progression. Therefore, to investigate the relationship between TGF-¥â receptors expression and carcinogenesis of bladder TCC, this study examined the expression of T ¥â R-I and T ¥â R-II in 46 bladder TCC patients using immunohistochemistry. Since histopathological grade is a widely accepted marker of prognosis, the results were compared in relation to the three grades of bladder TCC. The results demonstrated that the loss of TGF-¥â receptors expression is associated with increasing histopathological grades of bladder TCC. Specifically, both T ¥â R-I and T ¥â R-II were readily detected in all 10 normal bladder mucosa specimens. Likewise, all 6 specimens of grade I TCC samples expressed high levels of both TGF-¥â receptors. However, among grade II TCC samples, T ¥â R-I and T ¥â R-II were detected in 78% and 89%, respectively: among grade III TCC samples, T ¥â R-I and T ¥â R-II were detected in 45% and 41%, respectively. These results suggested that loss of sensitivity to TGF-¥â may play a role in the progression of TCC from low to high grade disease.
KEYWORD
Bladder transitional cell carcinoma, TGF-¥â receptor, tumor grade,
FullTexts / Linksout information
  
Listed journal information
SCI(E) MEDLINE ÇмúÁøÈïÀç´Ü(KCI) KoreaMed