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KMID : 0311119990400050439
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Yonsei Medical Journal
1999 Volume.40 No. 5 p.439 ~ p.443
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The Role of Radiotherapy in the Treatment of Aggressive Fibromatosis
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Kyoo Ho Shin
Sang Jin Shin/DooHee Lee/Eung Shick Kang/Chang Ok Suh
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Abstract
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Aggressive fibromatosis is a rare benign soft tissue tumor that is difficult to cure because of its infiltrative nature and high tendency to recur locally. The authors retrospectively analyzed 20 patients with histologically-confirmed fibromatosis. All patients underwent surgery with a wide or marginal margin. Five (25%) cases with histologically-negative margins had recurred. External beam radiotherapy was administered to patients whose margins were positive or who had local recurrence. However, out of concern for safety, radiotherapy was not given to two babies and a reproductive-aged woman. The average dose was 5,020 cGy. During the follow-up (mean 32.6 months), all the patients undergoing radiotherapy showed no evidence of local recurrence. A wide local excision has traditionally been the treatment of choice. However, postoperative radiotherapy could be an effective measure for preventing local recurrence in patients with a histologically-positive surgical margin and recurrence independent of any signs of relapse.
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KEYWORD
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Aggressive fibromatosis, surgery, radiatiotherapy, recurrence,
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