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KMID : 0311120000410050600
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Yonsei Medical Journal
2000 Volume.41 No. 5 p.600 ~ p.606
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Restoration of P-glycoprotein Function is Involved in the Increase of Natural Killer Activity with Exogenous Interleukin-15 in Human Immunodeficiency Virus-infected Individuals
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Kyung Hee Chang
June Myung Kim/Nae Choon Yoo/Won Ho Kim/Jeon Han Park/In Hong Choi/Hyun Sook Kim/Kyung Won Lee/Young Goo Song/Sung Kwan Hong/Hyo Yeul Kim
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Abstract
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A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases NK activity and induces the excretion of CC-chemokines from divergent immune cells, but the mechanisms of NK activity enhancement by IL-15 stimulation is not clearly established in HIV infection. This study examined whether CC-chemokines, which are known to increase NK activity, are secreted adequately in HIV-infected individuals, and also investigated whether P-glycoprotein is involved in NK activity enhancement after IL-15 administration. NK activity increased with IL-15 stimulation in NK cells of HIV-infected individuals, as it does in normal NK cells. IL-15 stimulates NK cells to secrete CC-chemokines, such as, macrophage inflammatory protein-1α (MIP-1α), macrophage chemotactic protein-1α (MCP-1α) and regulated upon activation, normal T cells expressed and secreted (RANTES) in both HIV-infected individuals and controls with no significant difference. P-glycoprotein expression and function is decreased in HIV-infected individuals and restored only in NK cells of HIV-infected individuals after IL-15 stimulation. P-glycoprotein may play a role in the mechanism of increased NK cell activity in HIV-infected individuals after IL-15 stimulation.
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KEYWORD
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Interleukin-15, NK cells, NK activity, HIV, P-glycoprotein,
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