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KMID : 0311120010420010055
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Yonsei Medical Journal
2001 Volume.42 No. 1 p.55 ~ p.64
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Hyperfractionated Re-irradiation using a 3-Dimensional Conformal Technique for Locally Recurrent Carcinoma of the Nasopharynx; Preliminary Results
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Jae Ho Cho
Gwi Eon Kim/Kwang Hwan Cho/Chang Geol Lee/Yong Bae Kim/Sang Wook Lee/Ki Chang Keum/Chang Ok Suh
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Abstract
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To evaluate the efficacy of hyperfractionated re-irradiation using a three-dimensional conformal radiotherapy (3-D CRT) technique in patients with locally recurrent carcinoma of the nasopharynx. Four patients with locally recurrent nasopharyngeal cancer were retreated with a hyperfractionated schedule using a 3-D CRT technique. Re-irradiation was delivered in 1.1-1.2 Gy fractions twice per day (BID), with interfraction intervals of more than 6 hours. The total dose ranged from 59.4 to 69.2 Gy. A 3-D CRT technique with 5- or 6-field coplanar and/or non-coplanar beams were employed during the entire treatment procedure. All four patients achieved complete remission of locally recurrent lesions, with marked improvement of subjective symptoms, immediately after re-irradiation. All are alive and well without evidence of disease after limited follow-up periods, which range from 7 to 20 months. So far, there have been no radiation-induced neurologic complications. Four patients with locally recurrent carcinoma of the nasopharynx were successfully treated by hyperfractionated re-irradiation using a 3-D CRT technique. A relatively high re-irradiation dose of more than 60 Gy may be safely delivered with no serious acute or late radiation-induced complications in patients with local recurrences and who were initially treated with doses greater than 70 Gy.
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