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KMID : 0311120070480020289
Yonsei Medical Journal
2007 Volume.48 No. 2 p.289 ~ p.294
Black Cohosh and St. John¡¯s Wort (GYNO-Plus(R)) for Climacteric Symptoms
Chung Da-Jung

Kim Hye-Yeon
Park Ki-Hyun
Jeong Kyung-Ah
Lee Sung-Ki
Lee Yu-Il
Hur Sung-Eun
Cho Min-Sun
Lee Byung-Seok
Bai Sang-Wook
Kim Cheong-Mee
Cho Si-Hyun
Hwang Ju-Youn
Park Joo-Hyun
Abstract
Purpose: This study was conducted to investigate the efficacy of black cohosh (Cimicifuga racemosa) and St. John¡¯s wort (Hypericum perforatum) in women with climacteric symptoms, and to assess their effects on vaginal atrophy, hormone levels, and lipid profiles.

Materials & Methods: In this double-blind randomized, placebo-controlled, multicenter study, 89 peri- or postmenopausal women experiencing climacteric symptoms were treated with St. John¡¯s wort and black cohosh extract (Gynoplus(R)), Jin-Yang Pharm., Seoul, Korea) or a matched placebo for 12 weeks. Climacteric complaints were evaluated by the Kupperman Index (KI) initially and at 4 and 12 weeks following treatment. Vaginal maturation indices, serum estradiol, FSH, LH, total cholesterol, HDL- cholesterol, LDL-cholesterol, and triglyceride levels were measured before and after treatment. From the initial 89 participants, 77 completed the trial (42 in the Gynoplus group, 35 in the placebo group).

Results: Baseline characteristics were not significantly different between the two groups. Mean KI scores and hot flushes after 4 and 12 weeks were significantly lower in the Gynoplus group. Differences in superficial cell proportion were not statistically significant. HDL levels decreased in the control group from 60.20 ¡¾ 16.37 to 56.63 ¡¾ 12.67, and increased in the Gynoplus group from 58.32 ¡¾ 11.64 to 59.74 ¡¾ 10.54; this was statistically significant (p=0.04).

Conclusion: Black cohosh and St. John¡¯s wort combination was found to be effective in alleviating climacteric symptoms and might provide benefits to lipid metabolism.
KEYWORD
Black cohosh, St. John¡¯s wort, climacteric symptoms
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