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KMID : 0311120070480020317
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Yonsei Medical Journal
2007 Volume.48 No. 2 p.317 ~ p.320
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Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation
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Jang Jae-Yong
Kim Soo-Chan
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Abstract
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We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein- Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and anti-EBV nuclear antigen IgG antibodies. To our knowledge, only one case of drug hypersensitivity syndrome (DHS) associated with EBV has been reported in the English- language literature. Our case is the second report of EBV-associated DHS, which suggests that EBV infection may contribute to the pathogenesis of AHS in a few patients.
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KEYWORD
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Carbamazepine, Epstein-Barr virus, hypersensitivity syndrome
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