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KMID : 0311120070480061066
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Yonsei Medical Journal
2007 Volume.48 No. 6 p.1066 ~ p.1071
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Extrapulmonary Small Cell Carcinoma of the Liver: Clinicopathological and Immunohistochemical Findings
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Choi Suk-Jin
Kim Joon-Mee
Han Jee-Young
Ahn Seung-Ik
Kim Jin-Soo
Kim Lucia
Park In-Suh
Chu Young-Chae
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Abstract
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Patients with primary small cell carcinoma of the liver have rarely been described in medical literature. Knowledge of clinical, pathological and immunohistochemical properties remains limited. We described an 82-year-old female patient with primary small cell carcinoma of the liver. Histologically, the tumor showed typical morphology of a pulmonary small cell carcinoma. Immunohistochemically, the tumor revealed neuroendocrine differentiation; positive reaction for chromogranin, synaptophysin, CD56, and neuron specific enolase. The tumor was also positive for TTF-1 and c-kit but completely negative for hepatocyte, carcinoembryonic antigen, cytokeratin 7; 19; and 20. Herein, we discussed the clinical, pathological and immunohistochemical findings of extrapulmonary small cell carcinoma of the liver and reviewed the relevant literature.
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KEYWORD
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Small cell carcinoma, neuroendocrine carcinoma, immunohistochemistry, liver
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