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KMID : 0311120080490010071
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Yonsei Medical Journal
2008 Volume.49 No. 1 p.71 ~ p.78
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The Relationship between Periodontal Status and Alkaline Phosphatase Levels in Gingival Crevicular Fluid in Men with Hypergonadotropic Hypogonadism
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Unsal Berrin
Isil Saygun
Ozlem Daltaban
Belgin Bal
Erol Bolu
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Abstract
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Purpose: The aim of this preliminary study was to determine the possible relationship between alkaline phosphatase (ALP) levels in the gingival crevicular fluid (GCF) and periodontal disease in men with hypergonadotropic hypogonadism (HH).
Materials and Methods: A total of 41 patients were divided into four groups. 9 with HH and periodontitis (P/HH), 11
with HH and gingivitis (G/HH), 12 with systemically healthy and periodontally healthy (H/C) and 9 with systemically
healthy and periodontitis (P/C). The clinical evaluation of patients was based on the following parameters; the plaque
index (PI), gingival index (GI), probing depths (PD) and attachment level (AL). The levels of ALP in the GCF were
measured by enzyme-linked immunosorbent assay (ELISA).
Results: No significant difference could be detected in the mean clinical parameter data between the P/HH and P/C groups (p > 0.05). The periodontitis patients in both groups (P/C and P/HH) had higher mean probing depths than the
H/C and G/HH patients (p < 0.001). The concentrations and total amounts of ALP in the GCF were significantly higher
in both periodontitis groups compared to healthy and gingivitis groups (p < 0.01). The serum ALP levels were
significantly higher in the P/HH group when compared to the other groups (p < 0.001).
Conclusion: The findings of this study suggested that HH could be implicated as a contributing factor to the progress of periodontal disease.
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KEYWORD
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Hypogonadism, alkaline phosphatase, gingival crevicular fluid, periodontal disease
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