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KMID : 0311120080490010119
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Yonsei Medical Journal
2008 Volume.49 No. 1 p.119 ~ p.128
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Comparison of Effects of Alendronate and Raloxifene on Lumbar Bone Mineral Density, Bone Turnover, and Lipid Metabolism in Elderly Women with Osteoporosis
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Jun Iwamoto
Yoshihiro Sato
Mitsuyoshi Uzawa
Tsuyoshi Takeda
Hideo Matsumoto
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Abstract
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Purpose: To compare the effects of alendronate and raloxifene on lumbar bone mineral density (BMD), bone
turnover, and lipid metabolism in elderly women with osteoporosis.
Subjects and Methods: One hundred twentytwo
postmenopausal women with osteoporosis (mean age: 69.4 years) were randomly divided into 2 groups of 61
patients: the alendronate group and the raloxifene group. BMD of the lumbar spine, urinary level of cross-linked
N-terminal telopeptides of type I collagen (NTX), and serum levels of alkaline phosphatase (ALP), total cholesterol (TC),
high and low density lipoprotein cholesterols (LDL-C and HDL-C, respectively), and triglycerides (TG) were measured
during the 12-month-treatment period.
Results: The trial in 50 patients in the alendronate group and 52 patients in the raloxifene group could be completed. Both alendronate and raloxifene increased lumbar BMD (+8.0% and +2.4% at 12 months, respectively), followed by reductions of urinary NTX level and serum ALP level; however, the effects of alendronate were more pronounced than those of raloxifene. Only raloxifene reduced the serum levels of TC and LDL-C (-3.9% and -7.7% at 12 months, respectively), without any significant effect on the serum HDL-C and TG levels.
Conclusion: The present study confirmed the efficacy of alendronate greater than raloxifene in increasing lumbar
BMD through its effect on marked reduction of the bone turnover more than by raloxifene, and some beneficial
effects of raloxifene on lipid metabolism in elderly women with osteoporosis.
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KEYWORD
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Alendronate, raloxifene, osteoporosis, postmenopausal women, lipid metabolism
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