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KMID : 0311120080490010155
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Yonsei Medical Journal
2008 Volume.49 No. 1 p.155 ~ p.158
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Rituximab-CHOP Induced Interstitial Pneumonitis in Patients with Disseminated Extranodal Marginal Zone B Cell Lymphoma
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Kim Kwang-Min
Hahm Jong-Ryeal
Kim Ho-Cheol
Kim Hoon-Gu
Lee Gyeong-Won
Kang Jung-Hun
Jeon Kyung-Nyeo
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Abstract
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A 69-year-old male was diagnosed in February 2004 with stage IV extranodal marginal zone B cell lymphoma involving
the mediastinal nodes, lung parenchyma and bone marrow with high LDH. Shortness of breath developed following the
5th course of Rituximab-CHOP chemotherapy (cyclophosphamide, Vincristine, Doxorubicin, Prednisolone). Bronchoscopy
guided transbronchial lung biopsy revealed interstitial thickening and type II pneumocyte activation, compatible with interstitial pneumonitis. After treatment with prednisolone a complete resolution of the dyspnea was observed. The patient
was well on routine follow-up at the outpatient clinic, with no progression of lymphoma or interstitial pneumonitis.
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KEYWORD
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Interstitial pneumonitis, rituximab, lymphoma
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