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KMID : 0311120080490030429
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Yonsei Medical Journal
2008 Volume.49 No. 3 p.429 ~ p.435
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Vascular Endothelial Growth Factor Levels in Ascites Between Chemonaive and Chemotreated Patients
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Lee Hye-Kyung
Kim Jin-Soo
Rho Sang-Young
Kim Hyung-Keun
Jang Hong-Seok
Han Kyung-Ja
Kang Jin-Hyoung
Cho Young-Seok
Chae Hiun-Suk
Cho Seok-Goo
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Abstract
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Purpose: Vascular endothelial growth factor (VEGF) levels in malignant ascites have high diagnostic value for their discrimination from asictes of non-malignant origin. However, there have been no reports on the comparison of VEGF levels between malignant ascites of chemonaive and chemotreated patients.
Materials and Methods: VEGF levels were measured in 44 ascites patients (cirrhosis ascites, 10; chemonaive patients, 21; chemotreated patients, 13) and compared to the level of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). The diagnostic parameters of sensitivity, specificity, and correlation among 3 markers were evaluated.
Results: VEGF levels in malignant ascites of chemonaive and chemotreated patients were significantly higher than those in cirrhotic ascites (p < 0.05). VEGF levels in ascites of chemonaive patients were significantly higher than those in chemotreated patients (p < 0.05). A cutoff value of 10.4pg/mL was calculated using receiver operating characteristic curves (ROCs) for VEGF in chemotreated and chemonaive patients, which gave sensitivities of 75.0% and 53.8% and specificities of 69.6% and 47.1%, respectively. Positive correlations were observed between VEGF and CEA (r = 0.353, p < 0.05) as well as between VEGF and CA19-9 (r = 0.367, p < 0.05) in ascites.
Conclusion: VEGF levels could be a useful tumor marker for malignant ascites, but its value should carefully be interpreted because of lesser reliability in chemotreated ones.
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KEYWORD
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Vascular endothelial growth factor, chemotherapy, malignant ascites, carbohydrate antigen 19-9, carcinoembryonic antigen
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