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KMID : 0311120080490050765
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Yonsei Medical Journal
2008 Volume.49 No. 5 p.765 ~ p.774
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Prostate Cancer: Added Value of Subtraction Dynamic Imaging in 3T Magnetic Resonance Imaging with a Phased-array Body Coil
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Yu Jeong-Sik
Chung Byung-Ha
Kim Ki-Whang
Chung Jae-Joon
Kim Joo-Hee
Hong Soon-Won
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Abstract
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Purpose: To determine the added value of dynamic subtraction magnetic resonance (MR) imaging for the localization of prostate cancer.
Materials and Methods: We examined 21 consecutive patients who underwent MR imaging in 3T unit with a phased-array body coil and then had radical prostatectomy. After T2-weighted fast spin-echo imaging, we performed a contrast-enhanced dynamic 3D gradient-echo imaging consisting of pre-contrast, 2 successive early-phased (first imaging was started just after the appearance of contrast material in the aortic bifurcation followed by second imaging 35 seconds after the initiation of first imaging) and one 5-minute delayed post-contrast series. Subtraction of pre-contrast images from corresponding post-contrast images of each phase was performed on the console.
Results: On ROC analysis, the overall accuracy (Az value) of dynamic imaging combined with subtraction imaging was higher than T2-weighted imaging (p = 0.001) or conventional dynamic imaging alone (p = 0.074) for localization of cancer foci regardless of their zonal locations. Among pathologically verified 81 lesions, the mean volume of detected lesions with the subtraction images (n = 49, 0.69cm3) was smaller than with T2-weighted images (n = 14, 1.05cm3) or conventional dynamic images (n = 43, 0.71cm3).
Conclusion: For localization of small prostate cancer, additional subtraction for the dynamic imaging could be superior to both T2-weighted imaging and un-subtracted dynamic imaging.
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KEYWORD
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Prostate, prostate cancer, magnetic resonance imaging, subtraction imaging, dynamic imaging
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