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KMID : 0311120080490050851
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Yonsei Medical Journal
2008 Volume.49 No. 5 p.851 ~ p.852
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Severe Acneiform Eruption Induced by Cetuximab (Erbitux®)
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Lee Jung-Eun
Lee Hee-Jung
Lee Ju-Hee
Lee Kwang-Hoon
Lee Sang-Joo
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Abstract
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Epidermal growth factor has an important role in the regulation of proliferation and differentiation in epidermal keratinocytes, as well as in the survival, angiogenesis and metastasis of cancer cells. Cetuximab is a chimeric monoclonal antibody selective for the epidermal growth factor receptor that induces a broad range of cellular responses that enhance tumor sensitivity to radiotherapy and chemotherapeutic agents. However, it can cause adverse events in the patient including acneiform eruption, asthenia, abdominal pain and nausea/vomiting. We report a case of severe acneiform eruption induced by cetuximab in a 56-year-old man with colorectal cancer and liver metastases.
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KEYWORD
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Cetuximab, acneiform eruption
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