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KMID : 0311120080490061055
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Yonsei Medical Journal
2008 Volume.49 No. 6 p.1055 ~ p.1059
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A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors
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Chang Joo-Hee
Kim Soon-Ki
Son Byong-Kwan
Lim Dae-Hyun
Kwon Young-Se
Kim Bok-Ki
Kim Joon-Mi
Lee Ji-Eun
Kang Sung-Gil
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Abstract
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We report a case of acute severe hepatitis with Mycoplasma pneumoniae (M. pneumoniae) infection and transient depression of multiple coagulation factors. A 5-year-old boy, previously healthy, was admitted with pneumonia. M. pneumoniae infection was confirmed by serology testing. Liver enzymes were elevated on admission without any past medical history. After treatment with azithromycin for 3 days, pneumonia improved, but the hepatitis was acutely aggravated. Partial thromboplastin time (PTT) was prolonged and depression of multiple coagulation factors developed. Liver biopsy revealed features consistent with acute hepatitis. A week later, liver enzymes were nearly normalized spontaneously. Normalization of prolonged PTT and coagulation factors were also observed several months later. This may be the first case of transient depression of multiple coagulation factors associated with M. pneumoniae infection.
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KEYWORD
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Hepatitis, Mycoplasma pneumoniae, depression, coagulation factors
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