|
KMID : 0311120090500040512
|
|
Yonsei Medical Journal
2009 Volume.50 No. 4 p.512 ~ p.516
|
|
|
Molecular Epidemiology of Hepatitis A Virus in the South-East Area of Gyeonggi-do in Korea
|
|
Song Han-Ul
Kwon Chang-Il
Ko Kwang-Hyun
Hong Sung-Pyo
Park Pil-Won
Hwang Seong-Gyu
Rim Kyu-Sung
Lee Ji-Eun
|
|
|
Abstract
|
|
|
Purpose: Hepatitis A virus (HAV) has been a leading cause of acute hepatitis in Korea. The reported genotypes of acute hepatitis A in Korea are the subgenotype IA and IB. The aim of the present study is to investigate HAV genotypes in the south-east area of Gyeonggi-do in Korea.
Materials and Methods: From June 2004 to June 2006, 46 acute hepatitis A patients were enrolled prospectively. All had sporadic acute hepatitis A patients. All suspected cases of acute hepatitis A were tested for IgM anti-HAV antibodies. We sequenced 168 bp of nucleotides of the putative VP1/P2A junction and determined the HAV genotype with reverse transcriptase polymerase chain reaction. The clinical and laboratory results of all patients were recorded.
Results: HAV-ribonucleic acid (RNA) was detected in 41 samples out of 46 samples. Among the 41 samples, 25 (60%) were shown to have subgenotype IIIA and the other 16 (40%) were subgenotype IA. Several amino acid substitutions were found.
Conclusion: In these HAV sporadic cases, IIIA and IA were identified, and this may reflect co-circulation of various genotypes in Korea. This study provides valuable new data on the genetic distribution of HAV and important information to help design appropriate public health measures.
|
|
|
KEYWORD
|
|
|
Hepatitis A, genotype, phylogeny, epidemiology, reverse transcriptase polymerase chain reaction
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
   
|